Nanotechnology-enabled Bromocriptine Delivery for Parkinson's Disease: Overcoming Pharmacokinetic Barriers and Advancing Brain Targeting

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31 Oct 2026 0 comments

INTRODUCTION: Bromocriptine (BRC) is a semi-synthetic ergot alkaloid and potent dopamine D2 receptor agonist used to manage a variety of dopamine dysfunction disorders. Over the past few decades, BRC has been used therapeutically for metabolic, endocrinological, and neurological disorders. Parkinson's disease (PD) is a progressive neurodegenerative disorder in which dopaminergic neurons in the substantia nigra degenerate, depleting the striatum of dopamine. Globally, PD affects nearly 1% of...