Glutamic acid decarboxylase (GAD)-65 antibodies-associated autoimmune neurological syndrome

Aggregator

01 Nov 2026 0 comments

Glutamic acid decarboxylase 65 antibody-associated neurological syndrome (GAD65-AINS) is an autoimmune disorder mediated by anti-GAD65 antibodies, with clinical phenotypes including stiff-person spectrum disorders(SPS), limbic encephalitis, cerebellar ataxia, and drug-resistant epilepsy. As the rate-limiting enzyme in GABA synthesis, GAD65 exhibits conformational plasticity, which forms the molecular basis for autoimmune targeting. Genetic susceptibility involves HLA regions (DR3, DR4) and...