Roles of Folate-Dependent Epigenetic Modifications in Major Depressive Disorder

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01 Nov 2026 0 comments

Major depressive disorder (MDD) is a complex psychiatric condition that affects over 280 million individuals globally. MDD etiology remains undefined; however, recent research demonstrates a significant link between epigenetics and its underlying molecular mechanisms. Epigenetic modifications such as DNA and histone methylation require methyl groups, with S-adenosylmethionine (SAM) serving as the methyl-group donor generated through one-carbon metabolism. Folate plays a crucial role in...