Sodium-Dependent Multivitamin Transporter Facilitates Brain and Neuronal Uptake of a Creatine Analogue

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04 Nov 2026 0 comments

Creatine transporter 1 (CRT1, SLC6A8) is a membrane transporter essential for importing creatine across the blood-brain barrier (BBB) into neurons and glial cells. Loss-of-function mutations in CRT1 result in creatine transporter deficiency syndrome (CTDS), a severe X-linked neurological disorder with no effective treatment. To explore alternative uptake pathways for creatine, a carrier-mediated delivery system utilizing the sodium-dependent multivitamin transporter (SMVT), a potential neuronal...