Hypoxic-ischemic brain damage (HIBD) represents a serious neurological disorder linked to ferroptosis, posing major clinical difficulties. This study investigates the neuroprotective role of formononetin (FMN), a natural antioxidant isoflavone, through its regulation of ferroptosis mediated by the Nrf2 pathway. In vivo , a neonatal mouse HIBD model is used, and FMN is administered alone or with the Nrf2 inhibitor ML385. Brain injury is evaluated via histopathological and functional tests....
Source: PubMed - functional neurological disorder
·Published 09 Nov 2026 ·Imported 09 Nov 2026
Relevancy: Not reviewed
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