IL-6 signaling drives treg dysfunction and pathogenic Th1-like polarization in major depressive disorder

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10 Nov 2026 0 comments

Major depressive disorder (MDD) is pathologically associated with inflammatory-immune dysregulation. While regulatory T cells (Tregs) are essential for immune homeostasis, clinical evidence have reported paradoxical dynamics (deficiency vs. expansion) of peripheral Tregs in MDD patients. The plasticity of Tregs and microenvironmental reprogramming mechanisms remain elusive, highlighting the need for pathology-driven biomarkers and targeted interventions. In this study, we integrated mass...