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Global epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis

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WHAT IS ALREADY KNOWN ON THIS TOPIC

  • Global systematic reviews of amyotrophic lateral sclerosis (ALS) epidemiology exist, but evolving demographic patterns and updated diagnostic criteria necessitate updated disease burden estimates.

    • WHAT THIS STUDY ADDS

  • This study provides updated pooled global estimates of ALS incidence, prevalence and mortality and confirms substantial heterogeneity in ALS disease burden across demographic, temporal, geographical and socioeconomic dimensions.

    • HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICY

  • These findings highlight multifaceted disease disparities attributable to genetic, environmental and socioeconomic factors, supporting healthcare policy making, optimised resource allocation and ongoing ALS research.

    • Introduction

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by progressive muscle weakness and atrophy, resulting from the degeneration of motor neurons in the cerebral cortex, brainstem and spinal cord.1 2 ALS is the most prevalent motor neuron disease...

    Source: JNNP - Current Issue · Published 13 Oct 2026 · Imported 17 Oct 2026

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