Network Pharmacology-Guided Identification of Orientin from Passiflora incarnata Reveals Neuroprotective Effects Against Glutamate-Induced Excitotoxicity Through Regulation of Calcium Homeostasis

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17 Oct 2026 0 comments

Epilepsy is a chronic neurological disorder in which current antiseizure medications are limited by incomplete seizure control and variable therapeutic responses, highlighting the need to identify new bioactive candidates. Passiflora incarnata (P. incarnata) has demonstrated neuropharmacological and anticonvulsant properties. However, the individual phytochemicals and molecular mechanisms underlying these effects remain incompletely characterized. In this study, we integrated network...