A Rat Model Mimicking Treatment-Induced Painful Diabetic Neuropathy Following Experimental Rapid Weight Loss

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17 Oct 2026 0 comments

CONCLUSION: These preliminary findings suggest that rapid weight reduction via caloric restriction combined with metformin may offer a feasible approach for establishing a TIND-like PDN rat model, and that rapid weight loss under diabetic conditions could be an important contributing factor in the conversion toward a painful neuropathy phenotype. Further studies with larger sample sizes are warranted to substantiate these observations.