Multimodal MRI biomarkers and machine learning in neuromyelitis optica spectrum disorder: a review

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17 Oct 2026 0 comments

Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing inflammatory demyelinating disease of the central nervous system that can result in substantial cumulative neurological disability. Magnetic resonance imaging (MRI) plays a central role in lesion detection, differential diagnosis, and longitudinal assessment. However, conventional MRI may not fully capture subtle tissue damage and may show substantial overlap with related inflammatory demyelinating disorders in clinically ambiguous...