Rethinking hyperhomocysteinemia: from causal risk factor to biomarker of glutathione deficiency in chronic diseases

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21 Oct 2026 0 comments

Hyperhomocysteinemia (HHcy) is a common metabolic disorder characterized by systemic elevation of the thiol amino acid homocysteine. Although HHcy is recognized as an independent risk factor for cardiovascular and many other chronic diseases, the causes and underlying mechanisms remain unclear despite decades of extensive research. The objective of this review is to critically examine the available literature in order to explore the hypothesis that endogenous glutathione deficiency may represent...