When Psychosis Masks Neurodegeneration: A Case of Sporadic Creutzfeldt-Jakob Disease

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21 Oct 2026 0 comments

We present a diagnostically challenging case of a 57-year-old male with new-onset persecutory delusions, hallucinations, functional decline, and gait instability following recent travel. While psychiatric features are recognised in Creutzfeldt-Jakob disease (CJD), they are often underappreciated as initial manifestations, leading to misdiagnosis and delayed recognition. Initially suspected to have a primary psychotic disorder, the patient's rapidly progressive course, neurological signs,...