hucMSC-sEVs restores intestinal epithelial homeostasis in inflammatory bowel disease via CKB-dependent creatine metabolism

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23 Oct 2026 0 comments

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by intestinal barrier dysfunction, excessive immune activation, and impaired epithelial homeostasis. Emerging evidence suggests that metabolic dysregulation contributes to disease progression. This study investigated whether human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hucMSC-sEVs) alleviate IBD by regulating creatine metabolism through creatine kinase B (CKB)-mediated...