Cell-Type-Specific Transcriptomic Alterations in the Epileptic Prefrontal Cortex and Complementary Neuroimaging Findings in an Independent Cohort

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24 Oct 2026 0 comments

CONCLUSIONS: The study identifies exploratory cell-type-specific transcriptional alterations in the public PFC dataset and, independently, metabolic and white matter microstructural abnormalities in a separate neocortical epilepsy cohort. These findings represent complementary observations across different biological scales rather than direct molecular-imaging validation. Larger donor-level transcriptomic studies, matched molecular-imaging cohorts, and functional experiments are required to...