Solid-State NMR Captures Time-Resolved Conformational Remodeling of Amelogenin Assemblies in Guiding Hydroxyapatite Morphogenesis

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24 Oct 2026 0 comments

Amelogenin is a major component in developing enamel protein matrix and plays a key role in regulating enamel mineral morphology. However, intrinsic disorder encoded in amelogenin's low-complexity regions leads to structural heterogeneity, thereby evading high-resolution characterization under physiological conditions. We hypothesize that amelogenin undergoes domain-specific rather than uniform structural and dynamic remodeling in regulating enamel apatite formation. Solid-state NMR (SSNMR),...