Decoding Zmiz1 : a key transcription coactivator in development and disease

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25 Oct 2026 0 comments

ZMIZ1, a zinc finger MIZ-type transcriptional co-activator in the PIAS family, is emerging as a central regulator at the interface of development and disease. Through interactions with key signaling effectors, including NOTCH1, SMAD3/4, p53, estrogen receptor, and androgen receptor, ZMIZ1 shapes transcriptional programs that govern embryogenesis, vascular and lymphatic development, and cerebral cortex development. Disruption of these programs is increasingly linked to human pathology: pathogenic...