Biomarkers and Prognostic Factors in Multiple System Atrophy: A Protocol for a Three-Year, Multicenter, Prospective, Longitudinal Cohort Study in Japan and South Korea

Aggregator

25 Oct 2026 0 comments

BACKGROUND: Multiple system atrophy (MSA) is a sporadic, adult-onset neurodegenerative disorder characterized by autonomic failure, Parkinsonism, and cerebellar ataxia. Early diagnosis remains a major unmet need because current clinical criteria often identify the disease only after considerable progression. The recently proposed Movement Disorder Society (MDS) prodromal MSA criteria provide a framework for earlier recognition; however, their specificity is limited. In particular, individuals...