Macamide B alleviates neuronal pyroptosis in spinal cord injury by activating acid ceramidase to inhibit lysosome membrane permeabilization

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25 Oct 2026 0 comments

Spinal cord injury is a devastating neurological disorder that causes severe and persistent functional deficits, for which effective pharmacological treatments remain limited. Acid ceramidase is a key lysosomal hydrolase involved in sphingolipid metabolism and has been implicated in cellular homeostasis and central nervous system disorders. However, its role in lysosomal membrane permeabilization and autophagic flux following spinal cord injury remains unclear. In this study, virtual screening...