Recognizing fibromyalgia-like pain phenotypes in lipedema: A narrative review

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25 Oct 2026 0 comments

IntroductionLipedema is a chronic adipose and connective tissue disorder in which pain is classically localized to affected limb tissue. However, some patients report joint, periarticular, myotendinous, or axial pain, with fatigue, sleep disturbance, and exercise intolerance. When symptoms become widespread, the presentation may resemble fibromyalgia (FM), creating a diagnostic challenge for phlebologists.ObjectivesTo provide a clinical framework for distinguishing characteristic lipedema tissue...