Nail-Patella Syndrome in a 76-Year-Old Woman: Multisystem Phenotype, Diagnostic Delay, and Clinical Implications

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27 Oct 2026 0 comments

Nail-patella syndrome (NPS) is a rare autosomal dominant multisystem disorder characterized by a variable combination of nail abnormalities, patellar hypoplasia or dysplasia, elbow involvement, and iliac horns, with possible renal, ophthalmological, neurological, and skeletal manifestations. Recognition may be substantially delayed when individual abnormalities are assessed separately or attributed to age-related and degenerative musculoskeletal disease. We report the case of a 76-year-old woman...