Prostaglandin E2 in Brain Inflammation: Roles and Dynamics

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27 Oct 2026 0 comments

Background/Objectives: Prostaglandin E2 (PGE(2)) is a known inflammatory mediator. It is produced by cyclooxygenase (COX)-1/2 during inflammation via four distinct G protein-coupled receptors (EP1-EP4). PGE(2) is involved in the development of brain diseases induced by acute and chronic stresses, although the mechanisms regulating PGE(2) concentration remain unclear. This review summarizes the mechanisms in relation to the activity of PGE(2), focusing on membrane transporters in...