Medically refractory epilepsy comorbid with psychogenic non-epileptic seizures and intellectual disability in a patient with balanced t(14;X) translocation: a case report

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28 Oct 2026 0 comments

CONCLUSIONS: This case highlights the complex interplay between epilepsy, psychiatric comorbidities, and neurostimulation, as well as the potential genetic underpinnings of TRE. The association of balanced X-autosome translocations with intellectual disability and epilepsy suggests pathogenic disruption of neurodevelopmental genes influencing inhibitory signaling. Awareness of psychiatric risks in DBS recipients and consideration of genetic etiologies are essential for optimizing management...