PubMed - diagnostic errors AND neurology Published 16 Oct 2026 Relevancy: 30%
CONCLUSIONS: Higher symptom scores were associated with poorer quality of life. Findings are exploratory and do not establish diagnostic or causal relationships.
Discuss (0) Read the articlePubMed - functional seizures Published 16 Oct 2026 Relevancy: 69%
Epilepsy is one of the most common chronic neurological disorders worldwide, affecting millions of individuals and imposing a substantial cognitive, psychological, social, and economic burden. Despite significant advances in epilepsy research, key questions remain unresolved regarding the mechanisms underlying drug resistance, cognitive impairment, depression, and sudden unexpected death in epilepsy, as well as the contribution of recurrent seizures in promoting neuronal and glial injury....
Discuss (0) Read the articlePubMed - functional seizures Published 16 Oct 2026 Relevancy: 18%
Bang sensitivity (BS) is a well-characterized seizure-and-paralysis phenotype in Drosophila melanogaster, but its genetic basis remains unexamined in the phylogenetically distant sister species Drosophila funebris. Here, we identify a naturally occurring BS strain in D. funebris from a wild population near Lake Valday, characterized by acute mechanical shock-induced seizures and paralysis, and examine its molecular-genetic and lipidomic basis. Comparative transcriptomics identified 241...
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Behind-the-ear electroencephalography (EEG) can now be recorded continuously outside hospital, but forecasting the preictal state is hard in a distributed deployment: raw traces cannot leave the clinical site, the wearable montage is chosen per patient, and part of the labelling comes from automated annotators rather than clinicians. Federated learning removes the need to move recordings, yet weighting each site by its sample count lets a poorly annotated site dominate the shared model. FedCareX...
Discuss (0) Read the articlePubMed - functional seizures Published 16 Oct 2026 Relevancy: 80%
OBJECTIVE: Guanidinoacetate methyltransferase (GAMT) deficiency is a rare autosomal recessive creatine biosynthesis disorder. Reports specifically focusing on adult patients remain scarce.
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CONCLUSION: VEEG demonstrated higher diagnostic performance than routine EEG, and EEG frequency band power was correlated with cognitive impairment severity.
Discuss (0) Read the articlePubMed - functional seizures Published 16 Oct 2026 Relevancy: 66%
CONCLUSION: The present study can expand the mutational spectrum of CDKL5 and highlight the clinical advantage of sequencing-based genetic testing for early diagnosis and personalized therapeutic management of refractory epilepsy.
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CONCLUSIONS: Imaging-based AI for predicting PSS and PSE has progressed rapidly, but important methodological and geographical gaps remain. Limited external validation, heterogeneous reporting, and the absence of African development and validation cohorts restrict confidence in the generalizability of existing models. Future research should prioritize the development of explainable imaging-based AI models using representative African neuroimaging datasets and their external validation in...
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CONCLUSIONS: Combined RNS with resection or ablation might provide meaningful seizure control in complex drug-resistant epilepsy with acceptable safety profiles. These findings describe current practice and support further investigation of hybrid surgical strategies in patients with challenging seizure networks as a potential treatment strategy.
Discuss (0) Read the articlePubMed - functional neurological disorder Published 16 Oct 2026 Relevancy: 35%
CONCLUSIONS: The findings of this analysis suggest that TBI is associated with alterations in the gut microbiome and that microbiota-targeted therapies involving probiotics may improve inflammatory, gut-barrier, neurological, and functional outcomes. Although substantial heterogeneity was observed across several outcomes, particularly the GCS, the available evidence supports further investigation of microbiome-directed interventions as adjunctive strategies for TBI management. Standardized...
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