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A Rat Model Mimicking Treatment-Induced Painful Diabetic Neuropathy Following Experimental Rapid Weight Loss

PubMed - small fiber neuropathy Published 06 Oct 2026 Relevancy: 28%

CONCLUSION: These preliminary findings suggest that rapid weight reduction via caloric restriction combined with metformin may offer a feasible approach for establishing a TIND-like PDN rat model, and that rapid weight loss under diabetic conditions could be an important contributing factor in the conversion toward a painful neuropathy phenotype. Further studies with larger sample sizes are warranted to substantiate these observations.

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Primary erythromelalgia associated with an SCN9A variant can mimic systemic lupus erythematosus in skin manifestations: A case report

PubMed - small fiber neuropathy Published 06 Oct 2026 Relevancy: 76%

Primary erythromelalgia (PEM) is a rare autosomal dominant disorder characterised by episodic erythema and burning pain of the extremities, typically triggered by exercise or fatigue. PEM usually begins in childhood and is caused by gain-of-function variants in SCN9A, which encodes the voltage-gated sodium channel Nav1.7. The disease concept of PEM, however, is largely unrecognised among rheumatologists. Here, we report a 20-year-old woman who had experienced recurrent burning pain and redness...

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Congratulations to @KarlDeisseroth and a fellow neurologist @michelle_monje! These discoveries advance the neuroscience and, hopefully, will eventually lead to a better understanding and new therapies for neurologic and psychiatric disorders.

Dr. Svetlana Blitshteyn Published 05 Oct 2026 Relevancy: 35%

Congratulations to @KarlDeisseroth and a fellow neurologist @michelle_monje ! These discoveries advance the neuroscience and, hopefully, will eventually lead to a better understanding and new therapies for neurologic and psychiatric disorders. Stanford University (@Stanford) The most important briefings of the day. Karl Deisseroth, professor of bioengineering and of psychiatry and behavioral sciences, shares the news of his Nobel Prize with his kids. Video — https://x.com/Stanford/status/2107133480220152219#m

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It's called Mast Cell Activation Syndrome (MCAS). The most frequent comorbidity of #MCAS is #POTS. Both POTS/#dysautonomia and MCAS are pathophysiologic mechanisms of #LongCOVID.

Dr. Svetlana Blitshteyn Published 05 Oct 2026 Relevancy: 85%

It's called Mast Cell Activation Syndrome (MCAS). The most frequent comorbidity of #MCAS is #POTS . Both POTS/ #dysautonomia and MCAS are pathophysiologic mechanisms of #LongCOVID . Tove Harris 🕊😷 (@NFMai) COVID-19 linked to increased risk of six allergic conditions in children and adults: atopic dermatitis, asthma, food allergy, rhinoconjunctivitis, medication allergy, urticaria. emjreviews.com/allergy-immun… Link COVID-19 Linked to Increased Risk of Six Allergic Conditions COVID-19 was associated with increased allergic disease risk over 18 months, with differing findings in children and service members. emjreviews.com — https://x.com/NFMai/status/2106760404462403807#m

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Small Fiber Neuropathy

PubMed - small fiber neuropathy Published 02 Oct 2026 Relevancy: 80%

OBJECTIVE: Small fiber neuropathy is a common disorder; however, its diagnosis and treatment can be challenging. This article outlines the pain pathways involved in small fiber neuropathy and provides an overview of its various causes, diagnostic tools, and therapeutic interventions.

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy

PubMed - autoimmune encephalitis AND misdiagnosis Published 02 Oct 2026 Relevancy: 82%

OBJECTIVE: This article describes the cardinal clinical, electrophysiologic, and supportive features of typical CIDP and its variants, how to review and apply CIDP diagnostic criteria, objective measures that can be used in practice to follow patients with CIDP, and current and emerging treatment practices.

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RT by @ZacharyGrinDPT: Here I outline principles evidence-based medicine, my lived experience, the mess with NICE #mecfs guidance @NICEComms and impacts on #longcovid guidance https://paulgarner.co.uk/sirpa-conference/

Zachary Grin Published 30 Sep 2026 FND proponent source Relevancy: 85%

Here I outline principles evidence-based medicine, my lived experience, the mess with NICE #mecfs guidance @NICEComms and impacts on #longcovid guidance paulgarner.co.uk/sirpa-confe… Link SIRPA Conference - Paul Garner In May 2025, an Association of practitioners of mind-body medicine, SIRPA, invited me to talk about my post-covid-19 condition and controversies in the field. The video is available here. paulgarner.co.uk

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Air pollution and the risk of multiple sclerosis relapses in the Paris region, the CONFISEP study

Journal of Neurology, Neurosurgery & Psychiatry - Online First Published 30 Sep 2026 Relevancy: 48%

Background Air pollution has been proposed as a short-term trigger of multiple sclerosis (MS) relapses, but delayed effects remain poorly studied in the era of modern disease-modifying therapies (DMTs). We investigated whether weekly air pollution exposure was associated with delayed MS relapse risk up to 15 weeks. Methods We conducted a bicentric retrospective cohort study in the Île-de-France region (2018–2021) including adults with relapsing MS from the Observatoire Francais de la Sclérose en Plaques registry. Weekly exposure to particulate matter (PM)10, PM2.5, nitrogen dioxide (NO2) and ozone (O3) was estimated using Airparif street-level modelling data. Associations (lags 0–15 weeks) were assessed using self-controlled case series and cohort analyses adjusted for time-varying DMTs, disease duration, number of relapses during the previous year, respiratory infections, temperature, sunlight exposure, lockdown and holiday periods and additionally for age, sex, deprivation index and urbanicity in cohort analyses. Results Among 1152 patients (73.6% women; median age 37 years), 898 relapses occurred (0.20/patient-year). In self-controlled analyses, PM10 exposure was associated with increased relapse risk at 2-week (incidence rate ratio (IRR) 1.28, 95% CI 1.05 to 1.57) and 11-week lags (IRR 1.26, 95% CI 1.02 to 1.54), PM2.5 exposure was associated with increased risk at 2-week (IRR 1.20, 95% CI 1.03 to 1.39), while NO2 exposure was associated with increased risk at 2-week (IRR 1.21, 95% CI 1.02 to 1.44), 3-week (IRR 1.26, 95% CI 1.04–1.52) and 12-week lags (IRR 1.32, 95% CI 1.12 to 1.56). Cohort analyses showed similar but weaker associations for PM10 and PM2.5. DMTs were strongly associated with lower relapse risk, with effect sizes greater than those observed for air pollution exposure. Conclusions Weekly exposure to PM10, PM2.5 and NO2 was associated with increased MS relapse risk over delayed time windows ranging from 2– 3 weeks to 11–12 weeks. These temporal windows should be considered exploratory given the multiple lag-specific analyses. DMTs remained the strongest determinants of relapse risk. Trial registration number NCT05033782.

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PABPN1 pathogenic expansion in the UK Biobank: reframing genetic prevalence of oculopharyngeal muscular dystrophy

Journal of Neurology, Neurosurgery & Psychiatry - Online First Published 30 Sep 2026 Relevancy: 66%

Background Oculopharyngeal muscular dystrophy (OPMD) is a rare, late-onset, mostly autosomal dominant muscular dystrophy caused by a trinucleotide GCN repeat expansion in PABPN1 . OPMD affects approximately 1:100 000 individuals in Europe, with substantially higher prevalence in specific founder populations. Pathogenic alleles encoding 12–18 alanine residues within the first exon show dosage effect, incomplete dominance and expression variability. The (GCN)11 allele has a prevalence of 1%–2% in the European population and is considered pathogenic in homozygosity. Conversely, heterozygous carriers might display mild, late-onset phenotypes, suggesting reduced penetrance. Methods We investigated whole exome sequencing data from 470 000 individuals in the UK Biobank cohort, by extracting PABPN1 rare (Minor Allele Frequency (MAF) < 0.001) coding (NM_004643.3) variants and focusing on the polyalanine tract. Demographic data and neuromuscular International Classification of Diseases, Tenth Revision (ICD-10) codes were collected. Results We identified 46 individuals with a genotype compatible with OPMD: 35 with a (GCN)12 genotype, 10 with a (GCN)13 genotype and 1 with a homozygous (GCN)11 genotype. In addition, 1896 individuals were heterozygous carriers of the (GCN)11 allele. The majority of (GCN)11 carriers did not present OPMD-compatible diagnostic codes, while OPMD-compatible diagnostic codes occurred in 11.4% of (GCN)12 carriers and rose to 70% of (GCN)13 carriers, showing a positive correlation between polyalanine tract length and clinical expression. Conclusions The cumulative genetic prevalence of pathogenic expansion was 1:10 200, 10 times higher than the estimated clinical prevalence. This analysis is relevant in the context of emerging therapeutic strategies targeting the PABPN1 polyalanine expansion.

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