NeurologyLive Published 17 Oct 2026 Relevancy: 29%
Leonard Dragone, MD, PhD, Disease Area Leader at Johnson & Johnson, discusses how nipocalimab is being incorporated into generalized MG care, what long-term data show, and where J&J sees the therapy’s role evolving.
Discuss (0) Read the articleNeurologyLive Published 17 Oct 2026 Relevancy: 34%
Neurology News Network for the week ending October 17th, 2026. [WATCH TIME: 4 minutes]
Discuss (0) Read the articlePubMed - small fiber neuropathy Published 17 Oct 2026 Relevancy: 83%
CONCLUSION: Pediatric SFN typically presents with a combination of POTS, neurologic, and GI symptoms. Our study demonstrates a potential autoimmune etiology, supported by the presence of identifiable autoantibodies and observed clinical improvement after a minimum of 3 months of IVIG therapy.
Discuss (0) Read the articlePubMed - functional seizures Published 17 Oct 2026 Relevancy: 38%
The adult hippocampus is highly susceptible to excitotoxic injury, although the extent to which acute seizure episodes dictate long-term cognitive outcomes through neurogenic niche remodeling remains incompletely understood. This study investigated the hypothesis that an isolated episode of sustained status epilepticus (SE) is sufficient to trigger persistent alteration of the adult neurogenic niche, followed by neurostructural and functional discrepancies. Acute SE was induced in young FVB/N...
Discuss (0) Read the articlePubMed - functional seizures Published 17 Oct 2026 Relevancy: 53%
CONCLUSIONS: HHV-6 and HHV-7 encephalitis in immunocompetent children share overlapping clinical characteristics and lack specific early laboratory or imaging features. CSF mNGS enabled rapid and unbiased detection of HHV-6 and HHV-7 sequences and provided complementary etiological information when interpreted together with clinical and ancillary findings.
Discuss (0) Read the articlePubMed - functional seizures Published 17 Oct 2026 Relevancy: 61%
CONCLUSION: In pediatric anti-NMDAR encephalitis, persistent CSF NMDAR antibodies at 12 months serve as a marker of incomplete remission and are associated with a trend toward a higher relapse rate and a significantly greater need for intensified immunotherapy, and may help identify patients who would benefit from more intensive immunomodulatory therapy.
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The parasympathetic nervous system is phylogenetically ancient. In humans, the vagus nerve is the brain's only pathway for bidirectional parasympathetic signaling with the thorax, abdomen, and upper pelvis. Unsurprisingly, the vagus nerve has played a significant role in scientific discovery and therapeutic applications, attracting the attention of Galen, Darwin, and Pavlov, among others. For example, Otto Loewi used the vagus nerve to gather data that confirmed Santiago Ramón y Cajal's Neuron...
Discuss (0) Read the articlePubMed - functional seizures Published 17 Oct 2026 Relevancy: 55%
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality and is typically characterized by a terminal cascade of respiratory failure, cardiac arrhythmia, and cerebral suppression. Although epilepsy has long been regarded as a neuron-proprietary disorder, accumulating evidence indicates that glial cells, particularly astrocytes, play pivotal roles in both epileptogenesis and the progression to SUDEP. Astrocytes maintain neuronal homeostasis by regulating...
Discuss (0) Read the articlePubMed - functional seizures Published 17 Oct 2026 Relevancy: 69%
CONCLUSION: VPS13A disease in this multicentre Indian cohort demonstrated substantial molecular heterogeneity, including apparently novel and recurrent variants. Longer intervals to tertiary evaluation were descriptively more frequent among patients with non-choreic presentations, particularly those with seizures, highlighting that clinicians need to maintain a high degree of suspicion for VPS13A even in such presentations.
Discuss (0) Read the articlePubMed - neurological misdiagnosis Published 17 Oct 2026 Relevancy: 45%
CONCLUSION: FLH can mimic common inflammatory or infectious hand masses. Magnetic resonance imaging (MRI) provides highly characteristic features that allow a clinicoradiological diagnosis, generally obviating the need for an invasive biopsy. Carpal tunnel decompression may provide symptomatic relief in patients with compressive neuropathy while avoiding potentially injurious intraneural resection.
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