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Biofluid Biomarkers of Neuronal and Glial Injury in Epilepsy and Seizures: A Comprehensive Review

PubMed - functional seizures Published 16 Oct 2026 Relevancy: 69%

Epilepsy is one of the most common chronic neurological disorders worldwide, affecting millions of individuals and imposing a substantial cognitive, psychological, social, and economic burden. Despite significant advances in epilepsy research, key questions remain unresolved regarding the mechanisms underlying drug resistance, cognitive impairment, depression, and sudden unexpected death in epilepsy, as well as the contribution of recurrent seizures in promoting neuronal and glial injury....

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The First Report of a Bang-Sensitive Strain in Drosophila funebris : Molecular-Genetic and Lipidomic Characterization

PubMed - functional seizures Published 16 Oct 2026 Relevancy: 18%

Bang sensitivity (BS) is a well-characterized seizure-and-paralysis phenotype in Drosophila melanogaster, but its genetic basis remains unexamined in the phylogenetically distant sister species Drosophila funebris. Here, we identify a naturally occurring BS strain in D. funebris from a wild population near Lake Valday, characterized by acute mechanical shock-induced seizures and paralysis, and examine its molecular-genetic and lipidomic basis. Comparative transcriptomics identified 241...

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