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A microglial basis for fragile X syndrome via impairment of FMRP-regulated lysosomal function

PubMed - functional seizures Published 18 Oct 2026 Relevancy: 35%

Silencing of the FMRP-encoding FMR1 gene results in fragile X syndrome (FXS), the most common inheritable intellectual disability and autism. FMRP regulates various neuronal functions but clinical trials targeting neurons have failed, suggesting unrecognized disease mechanisms. We find that mice with selective Fmr1 deletion in microglia exhibit audiogenic seizures (AGS) and parvalbumin (PV) neuron loss, recapitulating two key phenotypes observed in FXS (Fmr1^(-/y)) mice. By combining snRNA-Seq...

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The effect of resveratrol on the hippocampus in the pentylenetetrazol (PTZ) - dependent kindling model of epilepsy

PubMed - functional seizures Published 18 Oct 2026 Relevancy: 25%

CONCLUSION: RSV exerts significant neuroprotective effects in the PTZ kindling model by modulating the SIRT1-mediated stress response and preventing neuronal apoptosis. Notably, this study provides the first in vivo evidence that RSV modulates SERCA2a, CACNA1G, and HCN2 ion channel gene expressions to control intracellular calcium balance and neuronal excitability during epileptogenesis.

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RT by @recover2renew: It's much worse than the warnings suggest, the condition is called PSSD and is hell on earth. Just constant extreme suffering. Permanently. https://www.pssdnetwork.org

Marion Brown (Psychotherapist ) Published 17 Oct 2026 Relevancy: 30%

It's much worse than the warnings suggest, the condition is called PSSD and is hell on earth. Just constant extreme suffering. Permanently. pssdnetwork.org Link PSSD Network | Post-SSRI Sexual Dysfunction Post-SSRI Sexual Dysfunction is a condition in which sexual, cognitive, and emotional side effects don’t resolve after stopping antidepressants. pssdnetwork.org

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For prescribers … https://www.mims.co.uk/warnings-risk-suicidal-thoughts-antidepressants-strengthened-following-major-mhra-review/mental-health/article/1972712.

Marion Brown Published 17 Oct 2026 Relevancy: 25%

For prescribers … mims.co.uk/warnings-risk-sui… . Link Warnings about risk of suicidal thoughts with antidepressants strengthened, following major MHRA... The MHRA is introducing new measures to improve communication of key risks associated with antidepressants, including suicide and sexual dysfunction, following a major review. mims.co.uk

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