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Slow-wave sleep selectively amplifies network signatures of the presumed epileptogenic zone in focal epilepsy

PubMed - functional seizures Published 17 Oct 2026 Relevancy: 45%

CONCLUSIONS: Slow-wave sleep selectively unmasks pEZ network properties via amplified power, synchrony and hub topology. NREM3-derived multimodal features may complement conventional pre-surgical biomarkers. Prospective validation in larger cohorts is needed to determine whether these markers improve surgical planning and outcome prediction.

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Acute Status Epilepticus Triggers Long-Term Neurogenic Niche Destabilization That Undermines Cognitive Function in the Excitotoxic FVB/N Hippocampus

PubMed - functional seizures Published 17 Oct 2026 Relevancy: 38%

The adult hippocampus is highly susceptible to excitotoxic injury, although the extent to which acute seizure episodes dictate long-term cognitive outcomes through neurogenic niche remodeling remains incompletely understood. This study investigated the hypothesis that an isolated episode of sustained status epilepticus (SE) is sufficient to trigger persistent alteration of the adult neurogenic niche, followed by neurostructural and functional discrepancies. Acute SE was induced in young FVB/N...

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Clinical and metagenomic characterization of HHV-6 versus HHV-7 encephalitis in immunocompetent children

PubMed - functional seizures Published 17 Oct 2026 Relevancy: 53%

CONCLUSIONS: HHV-6 and HHV-7 encephalitis in immunocompetent children share overlapping clinical characteristics and lack specific early laboratory or imaging features. CSF mNGS enabled rapid and unbiased detection of HHV-6 and HHV-7 sequences and provided complementary etiological information when interpreted together with clinical and ancillary findings.

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Predictive value of persistent cerebrospinal fluid antibodies at 12 months for long-term clinical outcomes in pediatric anti-NMDAR encephalitis: a retrospective cohort study

PubMed - functional seizures Published 17 Oct 2026 Relevancy: 61%

CONCLUSION: In pediatric anti-NMDAR encephalitis, persistent CSF NMDAR antibodies at 12 months serve as a marker of incomplete remission and are associated with a trend toward a higher relapse rate and a significantly greater need for intensified immunotherapy, and may help identify patients who would benefit from more intensive immunomodulatory therapy.

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What happens in vagus

PubMed - functional seizures Published 17 Oct 2026 Relevancy: 25%

The parasympathetic nervous system is phylogenetically ancient. In humans, the vagus nerve is the brain's only pathway for bidirectional parasympathetic signaling with the thorax, abdomen, and upper pelvis. Unsurprisingly, the vagus nerve has played a significant role in scientific discovery and therapeutic applications, attracting the attention of Galen, Darwin, and Pavlov, among others. For example, Otto Loewi used the vagus nerve to gather data that confirmed Santiago Ramón y Cajal's Neuron...

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Astrocytes at the interface of peri-ictal breathing dysfunction and SUDEP

PubMed - functional seizures Published 17 Oct 2026 Relevancy: 55%

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality and is typically characterized by a terminal cascade of respiratory failure, cardiac arrhythmia, and cerebral suppression. Although epilepsy has long been regarded as a neuron-proprietary disorder, accumulating evidence indicates that glial cells, particularly astrocytes, play pivotal roles in both epileptogenesis and the progression to SUDEP. Astrocytes maintain neuronal homeostasis by regulating...

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Clinical and Genetic Spectrum of VPS13A Disease Across India: A Retrospective Multicentre Genetically Confirmed Cohort

PubMed - functional seizures Published 17 Oct 2026 Relevancy: 69%

CONCLUSION: VPS13A disease in this multicentre Indian cohort demonstrated substantial molecular heterogeneity, including apparently novel and recurrent variants. Longer intervals to tertiary evaluation were descriptively more frequent among patients with non-choreic presentations, particularly those with seizures, highlighting that clinicians need to maintain a high degree of suspicion for VPS13A even in such presentations.

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Fibrolipomatous Hamartoma of the Median Nerve Misdiagnosed as a Palmar Space Abscess: A Case Report

PubMed - neurological misdiagnosis Published 17 Oct 2026 Relevancy: 45%

CONCLUSION: FLH can mimic common inflammatory or infectious hand masses. Magnetic resonance imaging (MRI) provides highly characteristic features that allow a clinicoradiological diagnosis, generally obviating the need for an invasive biopsy. Carpal tunnel decompression may provide symptomatic relief in patients with compressive neuropathy while avoiding potentially injurious intraneural resection.

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Molecular Identification of Transthyretin Amyloid in Fixed Skin Biopsies: A Simplified Sample Preparation Method

PubMed - neurological misdiagnosis Published 17 Oct 2026 Relevancy: 70%

Hereditary transthyretin (TTR) amyloidosis (ATTRv) is associated with peripheral neuropathy resulting from the accumulation of fibrillar TTR amyloid deposits in tissues including peripheral nerves and skin. Accurate diagnosis requires molecular identification of amyloid deposits in tissue specimens. Skin punch biopsy is a minimally invasive, well-established diagnostic tool used to confirm small-fiber neuropathy. Congo-red (CR) staining confirms amyloid deposition but does not determine amyloid...

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