FND's Flawed Analogy: When 'Software' Problems can Hide Undetected Hardware Damage
One of the most common analogies that you would come across within Functional Neurological Disorder (FND) literature is the software/hardware analogy.
Basically, your CNS (that is, your brain, spinal cord, and signals carried via the PNS, the nerves) is described as hardware, while the processing of those signals that flow from that hardware is described as the software.
In this analogy, the CNS and PNS are considered structurally intact, while the processing of those signals (the software) is considered flaky or glitchy. They are believed to not be processing those signals properly and correctly.
The rule-in criteria (that is, the various patterns perceived by the clinician) are basically used to distinguish between hardware and software issues, comparable to a software developer looking at a stack trace or a computer technician looking at system event logs.
At this stage, when we start to elaborate or extend on the analogy, proponents tend to get a bit fidgety and annoyed, since the analogy is supposed to be partial and bound to a specific context and not really part of a broader, deeper, and more complex discussion, for example, "it's just a helpful metaphor, not literal" or "don't overcomplicate it".
Let's ignore the fluff. From here on, I will extend the analogy in my own way to illustrate the point.
Now admittedly, the CNS/PNS system is vastly more complex than any of our current computer systems.
However, I believe that reducing this complexity (that is, applying the Feynman technique here, reducing the CNS/PNS to a computer system) will prove useful as to why we cannot invoke a partial analogy here.
Okay, so many decades ago when I had just finished high school, I worked at a little computer repair shop as a technician. As a client brought in a computer, we would initially assess if we were dealing with hardware failure or simply software that went corrupt or awry in some other way.
Most of the time it was quite easy to assess the difference. Hardware problems tend to be quite easy to spot most of the time, since they tend to be quite dramatic at times, for example, a flickering screen from a damaged connector, rolling displays from a damaged graphics card, or even the smell of burnt circuits or capacitors.
And generally, when software issues arose, we could do a simple software update and in extreme cases we could simply back up data and just reformat the system and easily restore it back to its former glory.
But sometimes things were not this clean and easy.
Sometimes we would reinstall software only to discover later that the real problem was subtle hard-drive damage. Other times systems passed every stress test in our lab but failed immediately when the client used them in a specific way. In one case the problem turned out not to be the computer at all, but poor ventilation in the client's server room.
These are designed systems for which we have full specifications, and even then subtleties can be very tricky to find.
If diagnosing computers with full specifications can still miss subtle hardware faults, it should not surprise us that diagnosing the vastly more complex nervous system can also miss them.
As for humans themselves (that is, systems that evolved from other systems over billions of years), we do not have full specifications, only the ones we have discovered and are still discovering as we investigate medical issues. For example, as recently as 2020 Dutch researchers described the tubarial salivary glands.
If we take this back to the initial FND discussion, how many of these rule-in patterns are truly "software" issues and not rather a misunderstanding, misattribution, or an overreach?
Rule-in signs (like Hooverโs) function like basic diagnostics
For example, the facial asymmetry sometimes attributed to FND. In my wifeโs case we found actual reproducible mechanical actions that are directly responsible for what is seen.
The issue is not whether functional symptoms exist. The issue is whether the label is sometimes applied before the limits of structural investigation have truly been reached.
If a symptom is believed to be functional rather than structural, surely we cannot assume we already know what triggered it.
Surely we need to find triggers and monitor the situation instead of slapping a diagnostic label on it.
Why take the presentation of symptoms, give it a name, and push patients into therapy?
For example, if you go to a dentist with a sore tooth and the dentist cannot identify the source of the pain, in practice they would investigate triggers (for example, bruxism, diet, or posture), monitor the problem, and refer to specialists such as orofacial pain experts rather than declaring the pain โfunctionalโ.
FND risks becoming a diagnosis that closes investigation rather than one that manages uncertainty.
It is great to come up with hypotheses and dream up new ideas, but at the end of the day we need to acknowledge uncertainty and limitations. We cannot afford to treat unknowns as knowns; we need to keep diagnostic doors open. End of the day, you are not there to win some doctor an award. This is your life, this is your health.
References
- Neurosymptoms.org โ Patient Information on Functional Neurological Disorder
- The tubarial salivary glands: a potential new organ at risk for radiotherapy (Radiotherapy and Oncology, 2020)
- A practical review of functional neurological disorder (FND) for the general physician (Clin Med Lond, 2021) This review explains that Hooverโs sign, hip abductor sign and inconsistency between voluntary and automatic movements are reliable positive signs used to make a ruleโin diagnosis of FND.
- Systematic review of misdiagnosis of conversion symptoms and โhysteriaโ (BMJ, 2005)
The problem is you are assuming you understand everything there is to know about the 'mechanical' body and how it operates. Setting aside the bizarreness of FND claiming to get rid of the dichotomy between mind and body and in the next breath talking about hardware v software, lol, I see a far more complex picture. (For clarity I'm not arguing there is no such thing as a psychosomatic symptom, just that FND is a meaningless construct and is wildly overdiagnosed and inappropriately applied to large numbers of patients.) For example, ME/CFS is a proven biological disease - nobody with any credibility in biomedical research is even asking that question any more. There's mountains of published research, billions going into furthering the research - which may not have all the answers but is no longer at an early stage - and we know the disease impacts the whole body, and multiple systems. Researchers have so far identified in lab research116 differences in blood tests between those with ME and healthy controls (having matched for sedentary lifestyle). Some can correctly distinguish in lab tests between those with ME of different types and those who do have and do not have fibromyalgia. There are identified genes emerging as culprits with the second stage of the research under way to confirm the specific addresses, they are all associated with neuro and immune systems. The research is increasingly converging between teams and AI's applying NICE's GRADE analysis evaluate much of it as medium and some as potentially high and very significant - streets ahead of it's analysis of the scientific underpinnings of FND which are rated poor and very poor. Allocating ME/CFS to 'FND' is completely inappropriate. Similarly assuming epilepsy is FND until an (increasingly rare and brief) EEG captures a seizure to prove it's epilepsy is cruel, harmful and has done many patients devastating damage. We have real concerns. You can take a patient and with the same patient examined, same history, same symptoms, same test results and they will be diagnosed with ME/CFS by an ME specialist and as having FND by a neurologist - this isn't acceptable. It's undermining all the science behind ME. You stand a physio who specialises in neurology at the end of the ward and let them watch a patient walk normally from bed to bathroom, and then on the way back start to walk uncertainly - I've overheard the physio then saying look, he can walk normally if he's distracted, it's clearly FND. No it's not, it's the muscles running out of energy in ME. You can show them the patient walking uncertainly down a corridor, but then the phone by the bed rings and they walk normally to the phone to pick it up. The neuro is saying look the patient is distracted, they have FND. The ME specialist is saying look, the patient is taking time and care not to fall because they know their legs can give way, but when the phone goes it's more important to catch the call so they take the risk of walking faster (which they can do for a brief time before the energy in the muscles runs out). This isn't FND it's normal and rational behaviour in a patient who knows they have frequent falls. It's common sense, not a 'clinical sign'. An ME specialist shows his team training videos of doctors training doctors to diagnose FND and they are laughing at the patients on the video for being fooled by a name that makes it sound as though there's something wrong, when, ha ha ha, we all know there's nothing wrong, it's just in their imagination. It's all out there. The name has been invented to fool patients. You don't actually have a clue what's happening or what's causing it to the vast majority of these patients, but rather than admit it, you have invented something that makes life easier for you. It's the classic situation - the doctor looks seriously and kindly (because research has found you can manipulate people more easily if you are kind to them) and says 'I know your symptoms are real'. The patient hears 'your symptoms have a physical explanation'. The doctor means 'your symptoms are really psychosomatic'. Patients are being manipulated into taking a route into therapy which in the vast majority of patients has absolutely dire results.