FND's Flawed Analogy: When 'Software' Problems can Hide Undetected Hardware Damage

Author profile image Christoff Trรผter Spousal caregiver
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One of the most common analogies that you would come across within Functional Neurological Disorder (FND) literature is the software/hardware analogy. Neurosymptoms.org โ€“ Patient Information on Functional Neurological Disorder

Basically, your CNS (that is, your brain, spinal cord, and signals carried via the PNS, the nerves) is described as hardware, while the processing of those signals that flow from that hardware is described as the software.

In this analogy, the CNS and PNS are considered structurally intact, while the processing of those signals (the software) is considered flaky or glitchy. They are believed to not be processing those signals properly and correctly.

The rule-in criteria (that is, the various patterns perceived by the clinician) are basically used to distinguish between hardware and software issues, comparable to a software developer looking at a stack trace or a computer technician looking at system event logs.

At this stage, when we start to elaborate or extend on the analogy, proponents tend to get a bit fidgety and annoyed, since the analogy is supposed to be partial and bound to a specific context and not really part of a broader, deeper, and more complex discussion, for example, "it's just a helpful metaphor, not literal" or "don't overcomplicate it".

Let's ignore the fluff. From here on, I will extend the analogy in my own way to illustrate the point.

Now admittedly, the CNS/PNS system is vastly more complex than any of our current computer systems.

However, I believe that reducing this complexity (that is, applying the Feynman technique here, reducing the CNS/PNS to a computer system) will prove useful as to why we cannot invoke a partial analogy here.


Okay, so many decades ago when I had just finished high school, I worked at a little computer repair shop as a technician. As a client brought in a computer, we would initially assess if we were dealing with hardware failure or simply software that went corrupt or awry in some other way.

Most of the time it was quite easy to assess the difference. Hardware problems tend to be quite easy to spot most of the time, since they tend to be quite dramatic at times, for example, a flickering screen from a damaged connector, rolling displays from a damaged graphics card, or even the smell of burnt circuits or capacitors.

And generally, when software issues arose, we could do a simple software update and in extreme cases we could simply back up data and just reformat the system and easily restore it back to its former glory.

But sometimes things were not this clean and easy.

Sometimes we would reinstall software only to discover later that the real problem was subtle hard-drive damage. Other times systems passed every stress test in our lab but failed immediately when the client used them in a specific way. In one case the problem turned out not to be the computer at all, but poor ventilation in the client's server room.

These are designed systems for which we have full specifications, and even then subtleties can be very tricky to find.

If diagnosing computers with full specifications can still miss subtle hardware faults, it should not surprise us that diagnosing the vastly more complex nervous system can also miss them.

As for humans themselves (that is, systems that evolved from other systems over billions of years), we do not have full specifications, only the ones we have discovered and are still discovering as we investigate medical issues. For example, as recently as 2020 Dutch researchers described the tubarial salivary glands. The tubarial salivary glands: a potential new organ at risk for radiotherapy (Radiotherapy and Oncology, 2020)

If we take this back to the initial FND discussion, how many of these rule-in patterns are truly "software" issues and not rather a misunderstanding, misattribution, or an overreach?

Rule-in signs (like Hooverโ€™s) function like basic diagnostics A practical review of functional neurological disorder (FND) for the general physician (Clin Med Lond, 2021) This review explains that Hooverโ€™s sign, hip abductor sign and inconsistency between voluntary and automatic movements are reliable positive signs used to make a ruleโ€‘in diagnosis of FND. . They spot inconsistencies, but they do not rule out subtle hardware contributions any more than initial tests rule out bad sectors or ventilation problems. For instance, fluctuating neurological deficits caused by structural issues (such as dynamic compression, apraxia, ataxia etc) could potentially mimic patterns interpreted as inconsistency.

For example, the facial asymmetry sometimes attributed to FND. In my wifeโ€™s case we found actual reproducible mechanical actions that are directly responsible for what is seen.

The issue is not whether functional symptoms exist. The issue is whether the label is sometimes applied before the limits of structural investigation have truly been reached.

If a symptom is believed to be functional rather than structural, surely we cannot assume we already know what triggered it.

Surely we need to find triggers and monitor the situation instead of slapping a diagnostic label on it.

Why take the presentation of symptoms, give it a name, and push patients into therapy?

For example, if you go to a dentist with a sore tooth and the dentist cannot identify the source of the pain, in practice they would investigate triggers (for example, bruxism, diet, or posture), monitor the problem, and refer to specialists such as orofacial pain experts rather than declaring the pain โ€œfunctionalโ€.

FND risks becoming a diagnosis that closes investigation rather than one that manages uncertainty. Systematic review of misdiagnosis of conversion symptoms and โ€œhysteriaโ€ (BMJ, 2005)

It is great to come up with hypotheses and dream up new ideas, but at the end of the day we need to acknowledge uncertainty and limitations. We cannot afford to treat unknowns as knowns; we need to keep diagnostic doors open. End of the day, you are not there to win some doctor an award. This is your life, this is your health.

References
  1. Neurosymptoms.org โ€“ Patient Information on Functional Neurological Disorder
  2. The tubarial salivary glands: a potential new organ at risk for radiotherapy (Radiotherapy and Oncology, 2020)
  3. A practical review of functional neurological disorder (FND) for the general physician (Clin Med Lond, 2021) This review explains that Hooverโ€™s sign, hip abductor sign and inconsistency between voluntary and automatic movements are reliable positive signs used to make a ruleโ€‘in diagnosis of FND.
  4. Systematic review of misdiagnosis of conversion symptoms and โ€œhysteriaโ€ (BMJ, 2005)